论文标题
微流体障碍阵列中DNA溶液流的短距离循环图案
Short and Long-range cyclic patterns in flows of DNA solutions in microfluidic obstacle arrays
论文作者
论文摘要
我们观察到跨多个长度尺度出现的常规图案，在低雷诺数和高黛博拉的微流体支柱阵列中具有高浓度的DNA溶液。支柱之间的相互作用涡流导致远程顺序以高浓度和延伸的DNA组成的大型行进波的形式。波在柱子的二次阵列中形成，同时将柱子在二次阵列的每个晶胞中的位置随机，从而导致抑制远距离图案。我们发现，超过DNA重叠浓度的浓度可以使波动，并探索波的行为是流速，缓冲液组成，浓度和分子长度的函数，我们识别出弹性效应是波的起源。我们的工作不仅可能有助于增加通常限制微流体中样本处理的低通量，而且还可以为进一步研究基础粘弹性机制提供一个平台。
We observe regular patterns emerging across multiple length scales with high-concentration DNA solutions in microfluidic pillar arrays at low Reynolds numbers and high Deborah. Interacting vortices between pillars lead to long-range order in the form of large travelling waves consisting of DNA at high concentration and extension. Waves are formed in quadratic arrays of pillars, while randomizing the position of the pillar in each unit cell of a quadratic array leads to suppression of the long-range patterns. We find that concentrations exceeding the overlap concentration of the DNA enables the waves, and exploring the behavior of the waves as a function of flow rate, buffer composition, concentration and molecular length, we identify elastic effects as central to the origin of the waves. Our work may not only help increase the low throughput that often limits sample processing in microfluidics, it may also provide a platform for further studies of the underlying viscoelastic mechanisms.
