论文标题
基因组组织的3D聚合物模拟和跨不同染色体和细胞类型的转录
3D polymer simulations of genome organization and transcription across different chromosomes and cell types
论文作者
论文摘要
我们采用扩散的转录因子模型来模拟人类染色质的染色质拓扑结构和转录过程。简短染色质细丝的模拟显示了不同的调节转录的可能途径：显示转录活性曲线可以通过作用于链结构特性或外部因素（例如转录因子的数量）来调节和控制。此外，Gro-Seq实验数据和大规模数值模拟之间的比较，对人脐静脉内皮细胞的整个染色体和B-LMPHOCYTE GM12878的整个染色体进行了比较，表明该模型为不同细胞线的转录提供了可靠的统计学预测。
We employ the diffusing transcription factors model for numerical simulation of chromatin topology conformations and transcriptional processes of human chromatin. Simulations of a short chromatin filament reveal different possible pathways to regulate transcription: it is shown that the transcriptional activity profile can be regulated and controlled by either acting on the chain structural properties, or on external factors, such as the number of transcription factors. Additionally, comparisons between GRO-seq experimental data and large scale numerical simulation of entire chromosomes from the human umbilical vein endothelial cell and the B-lmphocyte GM12878 show that the model provides reliable and statistically significant predictions for transcription across different cell-lines.
