论文标题
通过锥形孔的易位：方向依赖的过程
Translocation through conical pores: A direction-dependent process
论文作者
论文摘要
生物分子在细胞膜上的转运是一种重要现象，在生物细胞的功能中起着关键作用。在本文中，我们通过通过锥形通道对聚合物的转运进行建模，该过程从更宽的开口到锥形通道的狭窄端进行建模。我们使用分子动力学方法来研究问题。不同的锥形孔几何形状和聚合物长度对易位动力学的影响取决于总易位时间，$τ$和等待时间分布的行为，即$ w（s）$。通过研究其速度曲线（$ v_ {s} $），可以跟踪聚合物段从锥形通道狭窄端的逃脱。为了证明对易位动力学的不对称孔影响，我们比较了锥形通道两端的易位过程。我们发现这两个过程的易位动力学差异与实验研究一致。我们已经说明了各种刚性的影响，以及聚合物链的长度对两种类型的过程的影响。该研究可用于通过不对称通道找到从方向依赖性到方向独立的转运过程的过渡。
The transport of biomolecules across a cell membrane is an important phenomena that plays a pivotal role in the functioning of biological cells. In this paper, we investigate such processes by modeling the translocation of polymers through a conical channel, directed from the wider opening to the narrow end of the conical channel. We use the molecular dynamics approach to study the problem. The effect of the different conical pore geometry and polymer lengths on translocation dynamics is determined from the behavior of the total translocation time, $τ$, and waiting time distributions, $w(s)$. The escape of polymer segments from the narrow end of the conical channel is tracked by studying their velocity profile ($v_{s}$). To demonstrate the asymmetric pore effects on the translocation dynamics, we compare the translocation process from both the ends of the conical channel. We find striking differences in the translocation dynamics for both processes, which are in agreement with the experimental study. We have accounted the effect of various rigidity, and increasing length of a polymer chain, on both types of processes. The study can be used to find the transition from a directional dependent to a directional independent translocation process through a asymmetric channel.
