论文标题
同源DNA双螺旋的直接配对可能涉及B到C形式过渡
Direct pairing of homologous DNA double helices may involve the B-to-C form transition
论文作者
论文摘要
在许多生物体中，在没有DNA断裂和重组的情况下，同源（或重复的）染色体区域可以将协同的表观遗传变化相关联。 DNA双链体与相似核苷酸序列的直接比配对代表了识别此类区域的有吸引力的机制。 B-DNA双链体的配对可能涉及大型能屏障，但C-DNA双链体有望更容易配对。 C-DNA的这一独特特征很大程度上是由于其主要的凹槽宽且非常浅，允许在两个双链体之间几乎完美的初始同源接触而无需冲突。总体而言，C-DNA在与重组无关的配对中的猜想作用应恢复理解其在细胞中的结构和功能的努力。
In many organisms, homologous (or repetitive) chromosomal regions can associate or/and undergo concerted epigenetic changes in the absence of DNA breakage and recombination. The direct specific pairing of DNA duplexes with similar nucleotide sequences represents an attractive mechanism for recognizing such regions. Whereas the pairing of B-DNA duplexes may involve a large energy barrier, C-DNA duplexes are expected to pair much more readily. This unique feature of C-DNA is largely due to the fact that its major groove is wide and very shallow, permitting almost perfect initial homologous contacts between two duplexes without clashing. Overall, the conjectured role of C-DNA in recombination-independent pairing should revive the efforts to understand its structure and function in the cell.
