论文标题
突变效应在选择饮用下的普遍性
Mutation Effect Generalizability under Selection-Drift
论文作者
论文摘要
尽管中立理论著名地描述了人群中离散遗传差异的数量，但我们考虑了观察到这种差异的遗传背景的数量 - 设定了其效果的概括性。这使我们能够确定在（1）环境和（2）遗传变异之间具有最大效应概括的种群结构和多样性率，并证明它们渐近地与（1）自然选择和（2）漂移下的人群相对应。同时，这些结果表明了在进化方案中适应性和进化的可预测性的明显限制。我们既采用宽敞的时间，大规模的基因组测序数据集（包括全基因组自相关计算）和精细的时间表条形码实验。
While Neutral Theory famously describes the number of discrete genetic differences in populations, we consider the number of genetic backgrounds under which such differences are observed - setting limits to the generalizability of their effects. This allow us to determine which population structures and diversity rates have maximal effect generalization across (1) environmental and (2) genetic variation, and to demonstrate that they correspond asymptotically to those of populations under (1) natural selection and (2) drift. At the same time, these results suggest distinct limits to the predictability of fitness and evolution across evolutionary regimes. We employ both broad time, large-scale genome sequencing datasets (including whole-genome autocorrelation calculations), and fine time-scale barcoding experiments.
