论文标题
小管蛋白组件中的多态性：一种机械模型
Polymorphism in tubulin assemblies: a mechanical model
论文作者
论文摘要
我们研究了二维小管蛋白组件中多态性结构的机械起源，其中微管是最著名的例子。这些结构具有扭曲的丝带，平坦小管蛋白片，大型管和箍，并且根据化学环境自发组装。在对小管蛋白进行建模为最小各向异性弹性壳并结合数值模拟和分析工作的组合后，我们表明，微管蛋白晶格中的机械应变来自单个二聚体水平的不对称性，自然而然地导致了圆锥形组合物和其他叶片结构的范围，这些均构成了一个构成的构成范围，这些均构成了一个预言量的序列。此外，我们的模型表明，将床单的自发高斯曲率从正（即球形）转换为负（即类似鞍形）的符号，可以为微管提供可能的途径。
We investigate the mechanical origin of polymorphic structures in two-dimensional tubulin assemblies, of which microtubules are the best known example. These structures feature twisted ribbons, flat tubulin sheets, macrotubules, and hoops, and they spontaneously assemble depending on the chemical environment. Upon modelling tubulin aggregates as minimally anisotropic elastic shells and using a combination of numerical simulations and analytical work, we show that the mechanical strain in tubulin lattices, originating from asymmetries at the single dimer level, naturally gives rise to polymorphic assemblies, among which cylinders and other tubular structures are predominant for a wide range of values of spontaneous curvature. Furthermore, our model suggests that switching the sign of the sheets' spontaneous Gaussian curvature from positive (i.e. sphere-like) to negative (i.e. saddle-like), could provide a possible route to microtubules disassembly.
