论文标题
使用Fokker-Planck框架，结肠癌诱导免疫反应的最佳个性化疗法
Optimal personalized therapies in colon-cancer induced immune response using a Fokker-Planck framework
论文作者
论文摘要
在本文中，提出了一个新的随机框架，以确定结肠癌诱导的免疫反应中的最佳联合疗法。结肠癌的动力学通过ITö随机过程进行了描述，其概率密度函数的演变受Fokker-Planck方程的控制。提出了开环控制优化问题，以确定最佳组合疗法。组合疗法的数值结果包括化学疗法药物\ ind {阿霉素}和免疫疗法药物IL-2验证了所提出的框架。
In this paper, a new stochastic framework to determine optimal combination therapies in colon cancer-induced immune response is presented. The dynamics of colon cancer is described through an Itö stochastic process, whose probability density function evolution is governed by the Fokker-Planck equation. An open-loop control optimization problem is proposed to determine the optimal combination therapies. Numerical results with combination therapies comprising of the chemotherapy drug \ind{Doxorubicin} and immunotherapy drug IL-2 validate the proposed framework.
