论文标题

实验室芯片光学生物传感器平台:与近红外傅立叶变换光谱仪集成的微环谐振器

Lab-on-a-Chip Optical Biosensor Platform: Micro Ring Resonator Integrated with Near-Infrared Fourier Transform Spectrometer

论文作者

Yoo, Kyoung Min, Hlaing, May, Jain, Sourabh, Fan, James, An, Yue, Chen, Ray T.

论文摘要

由于其高灵敏度和紧凑的装置尺寸,已经对基于evanevent场感应机制的微环传感器(MRR)光学生物传感器进行了广泛的研究。但是,必须在实验室芯片应用程序中证明合适的片上集成光谱仪设备,该设备可以根据折射率的微小变化来读取从MRR生物传感器的共振波长转移。在本文中,我们证明了近红外实验室芯片光学生物传感器平台的设计和实验结果,该平台在硅启用硅(SOI)晶圆上单一地整合了MRR和片上光谱仪,可以消除用于扫描波长的外部光谱分析仪。对称的加载力MRR生物传感器的设计为〜19 nm的自由光谱范围(FSR),并且散装灵敏度约为73 nm/riU;然后,从集成的空间内差傅立叶变换光谱仪(SHFTS)重建下降端口输出谐振峰,光谱分辨率约为3.1 nm,带宽为〜50 nm,从而导致检测到0.042 RIU的限制。用空气和水层的MRR输出光谱测量并从MRR-shfts集成设备进行实验中重建,以验证波长转移测量。

A micro-ring-resonator (MRR) optical biosensor based on the evanescent field sensing mechanism has been extensively studied due to its high sensitivity and compact device size. However, a suitable on-chip integrated spectrometer device has to be demonstrated for the lab-on-a-chip applications, which can read the resonance wavelength shift from MRR biosensors based on minuscule changes in refractive index. In this paper, we demonstrated the design and experimental results of the near-infrared lab-on-a-chip optical biosensor platform that monolithically integrates the MRR and the on-chip spectrometer on the silicon-on-insulator (SOI) wafer, which can eliminate the external optical spectrum analyzer for scanning the wavelength spectrum. The symmetric add-drop MRR biosensor is designed to have a free spectral range (FSR) of ~19 nm, and a bulk sensitivity of ~73 nm/RIU; then the drop-port output resonance peaks are reconstructed from the integrated spatial-heterodyne Fourier transform spectrometer (SHFTS) with the spectral resolution of ~3.1 nm and bandwidth of ~50 nm, which results in the limit of detection of 0.042 RIU. The MRR output spectrum with air- and water-claddings are measured and reconstructed from the MRR-SHFTS integrated device experimentally to validate the wavelength shifting measurement.

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