论文标题
巨噬细胞增殖的动脉粥样硬化的脂质结构数学模型
A lipid-structured mathematical model of atherosclerosis with macrophage proliferation
论文作者
论文摘要
我们扩展了福特等人的动脉粥样硬化斑块发育的脂质结构模型。 （2019）考虑巨噬细胞增殖。增殖被建模为脂质结构变量的非本地降低，该变量与大小结构化模型中的细胞分裂治疗相似（例如Efendiev等人（2018））。稳态分析表明，增殖有助于减少最终的坏死核心大小，并作用于细胞之间巨噬细胞种群的脂质负荷。还检查了斑块巨噬细胞通过从血液中增殖和募集的相对贡献。该模型表明，更加增殖的斑块与等效的（相同的脂质含量和细胞计数）募集识别仅以脂质分布在巨噬细胞之间的方式。
We extend the lipid-structured model for atherosclerotic plaque development of Ford et al. (2019) to account for macrophage proliferation. Proliferation is modelled as a non-local decrease in the lipid structural variable that is similar to the treatment of cell division in size-structured models (e.g. Efendiev et al. (2018)). Steady state analysis indicates that proliferation assists in reducing eventual necrotic core size and acts to spread the lipid load of the macrophage population amongst the cells. The relative contribution of plaque macrophages by proliferation and recruitment from the bloodstream is also examined. The model suggests that a more proliferative plaque differs from an equivalent (same lipid content and cell count) recruitment-dominant plaque only in the way lipid is distributed amongst the macrophages.
