论文标题
在深脑刺激手术期间，通过电阻断层扫描进行三维成像的后处理工具和可行性研究
A Post-Processing Tool and Feasibility Study for Three-Dimensional Imaging with Electrical Impedance Tomography During Deep Brain Stimulation Surgery
论文作者
论文摘要
电阻抗断层扫描（EIT）是生物医学成像的有前途的技术。 EIT的强度在于它通过辐射安全技术重建人体内部结构图像的能力。 EIT对患者的健康被认为是安全的，目前正在积极研究它。本文调查了深脑刺激（DBS）手术中EIT的应用，作为在操作过程中识别目标的一种手段。 DBS涉及手术程序，其中将铅或电极阵列植入大脑的特定目标区域。然后，电刺激用于调节目标区域内的神经回路，以减少残疾神经系统症状。进行DBS手术的主要困难是在开始治疗之前将铅精确定位在目标区域。与术前磁共振成像（MRI）或计算机断层扫描（CT）图像相比，DBS手术期间的脑组织移位可能与目标大小一样大。为了解决这个问题，提出了基于开放域EIT的解决方案，以重建DBS手术期间探测器周围的图像。进行了数据采集和图像重建，并应用了人工智能来增强所得图像。结果表明，所提出的方法是快速的，产生了有价值的高质量图像，并且构成了迈向体内研究的第一步。
Electrical impedance tomography (EIT) is a promising technique for biomedical imaging. The strength of EIT is its ability to reconstruct images of the body's internal structures through radiation-safe techniques. EIT is regarded as safe for patients' health, and it is currently being actively researched. This paper investigates the application of EIT during deep brain stimulation (DBS) surgery as a means to identify targets during operations. DBS involves a surgical procedure in which a lead or electrode array is implanted in a specific target area in the brain. Electrical stimulations are then used to modulate neural circuits within the target area to reduce disabling neurological symptoms. The main difficulty in performing DBS surgery is to accurately position the lead in the target area before commencing the treatment. Brain tissue shifts during DBS surgery can be as large as the target size when compared with the pre-operative magnetic resonance imaging (MRI) or computed tomography (CT) images. To address this problem, a solution based on open-domain EIT to reconstruct images surrounding the probe during DBS surgery is proposed. Data acquisition and image reconstruction were performed, and artificial intelligence was applied to enhance the resulting images. The results showed that the proposed method is rapid, produces valuable high-quality images, and constitutes a first step towards in-vivo study.
