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In this work, the integration of two machine learning approaches, namely domain adaptation and explainable AI, is proposed to address these two issues of generalized detection and explainability. Firstly the Domain Adversarial Neural Network (DANN) develops a generalized misinformation detector across multiple social media platforms DANN is employed to generate the classification results for test domains with relevant but unseen data. The DANN-based model, a traditional black-box model, cannot justify its outcome, i.e., the labels for the target domain. Hence a Local Interpretable Model-Agnostic Explanations (LIME) explainable AI model is applied to explain the outcome of the DANN mode. To demonstrate these two approaches and their integration for effective explainable generalized detection, COVID-19 misinformation is considered a case study. We experimented with two datasets, namely CoAID and MiSoVac, and compared results with and without DANN implementation. DANN significantly improves the accuracy measure F1 classification score and increases the accuracy and AUC performance. The results obtained show that the proposed framework performs well in the case of domain shift and can learn domain-invariant features while explaining the target labels with LIME implementation enabling trustworthy information processing and extraction to combat misinformation effectively.