论文标题
评估算法公平的表型定义
Assessing Phenotype Definitions for Algorithmic Fairness
论文作者
论文摘要
疾病鉴定是观察健康研究中的核心,常规活动。人群会影响下游分析,例如如何表征病情,定义患者的风险以及研究了哪些治疗方法。因此,至关重要的是要确保选定的队列代表所有患者,而与他们的人口统计学或社会决定因素无关。虽然在构建可能影响其公平性的表型定义时,有多种潜在的偏见来源,但在表型领域中考虑不同定义在患者亚组中的影响并不是标准。在本文中,我们提出了一组最佳实践来评估表型定义的公平性。我们利用预测模型中常用的既定公平指标,并将其与常用的流行病学同类群体描述指标相关联。我们描述了一项针对克罗恩病和2型糖尿病的实证研究,每个研究都有从两组患者亚组(性别和种族)中从文献中获取的多种表型定义。我们表明,根据不同的公平指标和亚组,不同的表型定义表现出广泛变化和不同的性能。我们希望提出的最佳实践可以帮助构建公平和包容的表型定义。
Disease identification is a core, routine activity in observational health research. Cohorts impact downstream analyses, such as how a condition is characterized, how patient risk is defined, and what treatments are studied. It is thus critical to ensure that selected cohorts are representative of all patients, independently of their demographics or social determinants of health. While there are multiple potential sources of bias when constructing phenotype definitions which may affect their fairness, it is not standard in the field of phenotyping to consider the impact of different definitions across subgroups of patients. In this paper, we propose a set of best practices to assess the fairness of phenotype definitions. We leverage established fairness metrics commonly used in predictive models and relate them to commonly used epidemiological cohort description metrics. We describe an empirical study for Crohn's disease and diabetes type 2, each with multiple phenotype definitions taken from the literature across two sets of patient subgroups (gender and race). We show that the different phenotype definitions exhibit widely varying and disparate performance according to the different fairness metrics and subgroups. We hope that the proposed best practices can help in constructing fair and inclusive phenotype definitions.