论文标题
心脏重新进入由时空混乱模型的耦合地图晶格
Cardiac Reentry Modeled by Spatiotemporal Chaos in a Coupled Map Lattice
论文作者
论文摘要
心律不齐是正常心律的致命破坏，但它们的潜在动态仍然很少了解。理论建模是填补这一空白的重要工具。典型的研究通常采用详细的基于多维电导的模型。我们用晶格中的三维基于图的膜电位模型来描述心肌。尽管地图保留了细胞的生物物理行为并产生计算有效的组织模型，但很少有研究使用它们来理解心脏动力学。我们的研究捕获了比电导模型更少的参数和简单方程的健康和病理行为。我们成功地概括了先前使用反应扩散系统获得的结果，显示了混乱的特性如何重新进入，这是一种以复杂的时空特征发展到心律不齐的刺激的病理传播。单细胞的分叉图与基于详细电导的模型中获得的分叉图非常相似。我们使用螺旋波中的整个网络的一般采样，发现心电图中某些类型心动过速的扭转尖端是某些类型的心动过速的临床表现。我们还发现了一种新型的动力模式，波前由同步心脏平台和爆发组成。我们的研究提供了第一个深入的研究，探讨了使用基于地图的模型模拟复杂心脏动力学的使用。
Arrhythmias are potentially fatal disruptions to the normal heart rhythm, but their underlying dynamics is still poorly understood. Theoretical modeling is an important tool to fill this gap. Typical studies often employ detailed multidimensional conductance-based models. We describe the cardiac muscle with a three-dimensional map-based membrane potential model in lattices. Although maps retain the biophysical behavior of cells and generate computationally efficient tissue models, few studies have used them to understand cardiac dynamics. Our study captures healthy and pathological behaviors with fewer parameters and simpler equations than conductance models. We successfully generalize results obtained previously with reaction-diffusion systems, showing how chaotic properties result in reentry, a pathological propagation of stimuli that evolves to arrhythmias with complex spatiotemporal features. The bifurcation diagram of the single cell is very similar to that obtained in a detailed conductance-based model. We find torsade de pointes, a clinical manifestation of some types of tachycardia in the electrocardiogram, using a generic sampling of the whole network during spiral waves. We also find a novel type of dynamical pattern, with wavefronts composed of synchronized cardiac plateaus and bursts. Our study provides the first in-depth look at the use of map-based models to simulate complex cardiac dynamics.
