论文标题
关于SARS-COV-2病毒的Omicron变体的起源
On the origins of the Omicron variant of the SARS-CoV-2 virus
论文作者
论文摘要
提出了基于第一原理的可能解释，以涉及与HIV共感染SARS-COV-2病毒的Omicron变体。要点是，由此产生的HIV诱导的免疫功能使SARS-COV-2更大的纬度探索其自身的突变空间。这个纬度不是疏离的，并且探索了特定的生物物理约束。具体而言，在尖峰糖蛋白的蛋白质数据库文件中观察到骨架氢键中的近两到五倍的差异，得出两个结论：峰值的诱变残基在峰值的受体结合亚基中不经常参与Backbone Hydrogogen hydogen hydogen Bonds中。因此，一种病毒逃生的技术是在物理化学和功能限制内消除此类键。以前的讨论完全独立的早期工作从自由能的一般原理（即糖蛋白的亚稳定性）中解释了这些现象。因此，结论可能更普遍地作为病毒学原则。
A possible explanation based on first principles for the appearance of the Omicron variant of the SARS-CoV-2 virus is proposed involving coinfection with HIV. The gist is that the resultant HIV-induced immunocompromise allows SARS-CoV-2 greater latitude to explore its own mutational space. This latitude is not withoutr estriction, and a specific biophysical constraint is explored. Specifically, a nearly two- to five-fold discrepancy in backbone hydrogen bonding is observed between sub-molecules in Protein Data Bank files of the spike glycoprotein yielding two conclusions: mutagenic residues in the receptor-binding subunit of the spike much more frequently do not participate in backbone hydrogen bonds; and a technique of viral escape is therefore to remove such bonds within physico-chemical and functional constraints. Earlier work, from which the previous discussion is entirely independent, explains these phenomena from general principles of free energy, namely, the metastability of the glycoprotein. The conclusions therefore likely hold more generally as principles in virology.
