论文标题
癌症转移中集体细胞迁移的生物物理和生化机制
Biophysical and Biochemical mechanisms underlying Collective Cell Migration in Cancer Metastasis
论文作者
论文摘要
多细胞集体迁移是在各种组织环境中空间易位的细胞的普遍策略，以完成各种生物学现象，即。胚胎发育，伤口愈合和肿瘤进展。各种细胞功能和行为，例如细胞突起，主动收缩，细胞 - 细胞粘附，生化信号传导，组织微环境的重塑等，同时发挥了自己的作用，以产生多细胞迁移的单一协调性结果。因此，揭示了固有复杂的集体细胞迁移过程的生化和生物物理的驾驶原则是一项无法克服的任务。与实验数据同时，数学和计算模型有助于阐明它。在这里，我们回顾了影响集体细胞迁移的不同因素，然后专注于不同的数学和计算模型（离散，混合和连续体），这有助于揭示多细胞迁移的不同方面。最后，我们讨论了这些模型框架的应用
Multicellular collective migration is a ubiquitous strategy of cells to translocate spatially in diverse tissue environments to accomplish a wide variety of biological phenomena, viz. embryonic development, wound healing, and tumor progression. Diverse cellular functions and behaviors, for instance, cell protrusions, active contractions, cell-cell adhesion, biochemical signaling, remodeling of tissue micro-environment, etc., play their own role concomitantly to have a single concerted consequence of multicellular migration. Thus unveiling the driving principles, both biochemical and biophysical, of the inherently complex process of collective cell migration is an insurmountable task. Mathematical and computational models, in tandem with experimental data, help in shedding some light on it. Here we review different factors influencing Collective Cell Migration and then focus on different mathematical and computational models - discrete, hybrid, and continuum - which helps in revealing different aspects of multicellular migration. Finally, we discuss the applications of these modeling frameworks specific to cancer
