论文标题
血液和血液模拟剂对固体表面的影响：红细胞的可变形性和等离子体的弹性
Droplet impact of blood and blood simulants on a solid surface: Effect of the deformability of red blood cells and the elasticity of plasma
论文作者
论文摘要
先前的研究表明，影响血液的行为类似于牛顿液的行为，牛顿液的剪切粘度等于血液的剪切速率高。为了理解这一重要事实，我们使用全血和三种溶液对玻璃表面进行了比较实验，其剪切粘度类似于血液。具体而言，我们使用了狗的全血（分散在血浆，WB中的可变形红细胞），具有不可变形的树脂颗粒（PWP），甘油和水树脂颗粒（GWWP）（GWWP）的血浆（PWP），以及商用的血液模拟剂（硬粒子分散在水性牛顿溶液中，bs）。在我们的实验中，雷诺和韦伯的范围分别为550美元<re <$ <$ 1700和120美元$ <We <$ 860。两台高速摄像机同时记录了液滴冲击的侧面和底部视图。在我们的实验中，影响WB液滴的扩散半径与粘度类似于WB的牛顿流体以高剪切速率的粘度非常吻合。 WB和牛顿流体的飞溅液滴形成手指结构（手指裂解）。尽管PWP的粘度与WB的粘度相似，但剪切速率高，但影响的PWP液滴表现出影响悬浮液滴的典型特征，也就是说，散布半径降低并随着颗粒的喷射而飞溅。影响PWP和WB的液滴之间的这种显着差异表明，WB中红细胞的高变形性在血液液滴对撞击的牛顿样行为中起着至关重要的作用。重要的是，影响的BS液滴的行为与WB在扩散和溅起时的行为截然不同。我们的结果表明，在BS中使用可变形颗粒而不是硬粒子对于模仿血液液滴撞击至关重要。
Previous studies suggest that the behaviour of impacting blood is similar to that of a Newtonian fluid, which has a shear viscosity equivalent to that of blood at high shear rates. To understand this important fact, we conducted comparative experiments of droplet impact on a glass surface using whole blood and three solutions with a shear viscosity similar to that of blood. Specifically, we used dog's whole blood (deformable red blood cells dispersed in plasma, WB), plasma with non-deformable resin particles (PwP), glycerol and water with resin particles (GWwP), and a commercial blood simulant (hard particles dispersed in a water-based Newtonian solution, BS). The ranges of Reynolds and Weber numbers in our experiments were 550 $<Re<$ 1700 and 120 $<We<$ 860, respectively. Side and bottom views of droplet impact were simultaneously recorded by two high-speed cameras. The spreading radius of the impacting WB droplet in our experiments agreed well with that of Newtonian fluids with viscosity similar to that of WB at high shear rates. Splashing droplets of WB and Newtonian fluids form finger structures (finger-splashing). Although PwP has a viscosity similar to that of WB at high shear rates, an impacting PwP droplet exhibited typical characteristics of impacting suspension droplets, that is, a reduced spreading radius and splashing with ejection of particles. Such significant differences between impacting droplets of PwP and WB indicates that the high deformability of red blood cells in WB plays a crucial role in the Newtonian-like behaviour of blood droplets on impact. Importantly, the impacting BS droplet behaved quite differently from WB in both spreading and splashing. Our results imply that the use of deformable particles rather than hard particles in a BS is essential for mimicking blood droplet impact.
