论文标题
从单一到集体细胞迁移的桥接：模型和实验链接的综述
Bridging from single to collective cell migration: A review of models and links to experiments
论文作者
论文摘要
数学和计算模型可以有助于了解组织许多级别的细胞行为。在这里，我们回顾了文献中的模型，该模型侧重于3个尺寸尺度上的真核细胞运动：细胞内信号传导，可调节细胞形状和运动，单细胞运动，以及从几个细胞到组织的集体细胞行为。我们调查了最近的文献，以总结不同的计算方法（相位场，多边形，细胞Potts和球形细胞）。我们讨论了模型中包含的组织水平之间桥接的模型，并描述了模型中包括生化和几何的细节水平。我们还强调了模型和实验之间的联系。我们发现，跨越三个级别的模型仍在少数群体中。
Mathematical and computational models can assist in gaining an understanding of cell behavior at many levels of organization. Here, we review models in the literature that focus on eukaryotic cell motility at 3 size scales: intracellular signaling that regulates cell shape and movement, single cell motility, and collective cell behavior from a few cells to tissues. We survey recent literature to summarize distinct computational methods (phase-field, polygonal, Cellular Potts, and spherical cells). We discuss models that bridge between levels of organization, and describe levels of detail, both biochemical and geometric, included in the models. We also highlight links between models and experiments. We find that models that span the 3 levels are still in the minority.
