论文标题
动态核结构来自染色质交联和电动机
Dynamic nuclear structure emerges from chromatin crosslinks and motors
论文作者
论文摘要
细胞核包含染色体，这些染色体与层粘蛋白丝的软壳有关。实验表明，相关的染色体动力学和核形状波动是由运动活性引起的。为了识别物理机制，我们开发了一个与聚合物壳结合的主动的，交联的Rouse链的模型。系统大小的相关运动发生，但需要运动活动{\ it和}交联。尤其是收缩电动机通过驱动异常密度波动来增强染色体动力学。核形状的波动取决于运动强度，交联和染色体 - 薄膜结合。因此，复杂的染色质动力学和核形状从最小的活性染色体 - 薄膜系统中出现。
The cell nucleus houses the chromosomes, which are linked to a soft shell of lamin filaments. Experiments indicate that correlated chromosome dynamics and nuclear shape fluctuations arise from motor activity. To identify the physical mechanisms, we develop a model of an active, crosslinked Rouse chain bound to a polymeric shell. System-sized correlated motions occur but require both motor activity {\it and} crosslinks. Contractile motors, in particular, enhance chromosome dynamics by driving anomalous density fluctuations. Nuclear shape fluctuations depend on motor strength, crosslinking, and chromosome-lamina binding. Therefore, complex chromatin dynamics and nuclear shape emerge from a minimal, active chromosome-lamina system.
