论文标题
最佳的矫正，而无需通过生物分子运动抑制前电流抑制
Optimal rectification without forward-current suppression by biological molecular motor
论文作者
论文摘要
我们通过实验表明，生物分子电机F $ _1 $ -ATPase（F $ _1 $）实现了最佳的整流机制。 f $ _1 $几乎不能抑制三磷酸腺苷（ATP）合成，这是f $ _1 $的生理作用，同时抑制对ATP的不利水解。这种最佳的整流是与简单的棘轮模型的高对比度，在这种模型中，对向后电流的抑制不可避免地伴随着对正向电流的抑制。单分子轨迹的详细分析表明，具有平行景观和不对称过渡速率的F $ _1 $的新颖但简单的整流机制。
We experimentally showed that biological molecular motor F$_1$-ATPase (F$_1$) implements an optimal rectification mechanism. F$_1$ hardly suppresses adenosine triphosphate (ATP) synthesis, which is the F$_1$'s physiological role while inhibiting unfavorable hydrolysis of ATP. This optimal rectification is a high contrast to a simple ratchet model, where the inhibition of the backward current is inevitably accompanied by the suppression of the forward current. The detailed analysis of single-molecule trajectories demonstrated a novel but simple rectification mechanism of F$_1$ with parallel landscapes and asymmetric transition rates.
