论文标题
将基于MRI的中风分析的深神经网络中的不确定性整合
Integrating uncertainty in deep neural networks for MRI based stroke analysis
论文作者
论文摘要
目前,大多数提出的深度学习(DL)方法提供了点预测,而无需量化模型不确定性。但是,对自动图像分析的可靠性的量化至关重要,特别是当医生依靠结果来做出关键治疗决策时。在这项工作中,我们提供了一个整个框架,以诊断将贝叶斯不确定性纳入分析程序中的缺血性中风患者。我们提出了一个贝叶斯卷积神经网络(CNN),在2D磁共振图像(MR)图像上产生了中风病变的概率,该图像具有有关预测可靠性的相应不确定性信息。对于患者级诊断,提出和评估了不同的聚合方法,这些方法结合了单个图像级预测。这些方法利用了图像预测中的不确定性,并报告了患者级别的模型不确定性。在511名患者的队列中,我们的贝叶斯CNN在图像级别的准确度达到95.33%,代表非bayesian的同行的2%显着提高。最好的患者聚集方法产生了95.89%的精度。在聚合模型中整合有关图像预测的不确定性信息导致对错误的患者分类的不确定性度量更高,这使得能够过滤临界的关键患者诊断,这些诊断本应仔细检查医生。因此,我们建议使用贝叶斯方法不仅用于改进图像级预测和不确定性估计,还用于检测患者级别的不确定聚集。
At present, the majority of the proposed Deep Learning (DL) methods provide point predictions without quantifying the models uncertainty. However, a quantification of the reliability of automated image analysis is essential, in particular in medicine when physicians rely on the results for making critical treatment decisions. In this work, we provide an entire framework to diagnose ischemic stroke patients incorporating Bayesian uncertainty into the analysis procedure. We present a Bayesian Convolutional Neural Network (CNN) yielding a probability for a stroke lesion on 2D Magnetic Resonance (MR) images with corresponding uncertainty information about the reliability of the prediction. For patient-level diagnoses, different aggregation methods are proposed and evaluated, which combine the single image-level predictions. Those methods take advantage of the uncertainty in image predictions and report model uncertainty at the patient-level. In a cohort of 511 patients, our Bayesian CNN achieved an accuracy of 95.33% at the image-level representing a significant improvement of 2% over a non-Bayesian counterpart. The best patient aggregation method yielded 95.89% of accuracy. Integrating uncertainty information about image predictions in aggregation models resulted in higher uncertainty measures to false patient classifications, which enabled to filter critical patient diagnoses that are supposed to be closer examined by a medical doctor. We therefore recommend using Bayesian approaches not only for improved image-level prediction and uncertainty estimation but also for the detection of uncertain aggregations at the patient-level.