论文标题
使用钻石量子传感器从活哺乳动物肌肉中检测生物信号
Detection of biological signals from a live mammalian muscle using a diamond quantum sensor
论文作者
论文摘要
在生物医学中，对动作电位产生的电信号进行无创，非接触式测量的能力是必不可少的。这样做的一个关键方法是通过它们诱导的磁场远程感知信号。现有用于哺乳动物组织的磁场传感的方法，用于诸如大脑磁脑摄影的技术，需要低温冷却的超导检测器。这些在高成本，灵活性和有限的便携性以及差的空间和时间分辨率方面都有许多缺点。在这项工作中，我们展示了一种用于检测钻石中氮空位中心在活组织中的动作电位产生的磁场的替代技术。使用50pt/$ \ sqrt {hz} $灵敏度，我们使用钻石传感器使用小鼠肌肉光源于蓝光激活了乳腺组织的第一个测量。我们显示这些测量值可以在普通的，非屏蔽的实验室环境中执行，并且可以通过数字信号处理技术轻松恢复信号。
The ability to perform noninvasive, non-contact measurements of electric signals produced by action potentials is essential in biomedicine. A key method to do this is to remotely sense signals by the magnetic field they induce. Existing methods for magnetic field sensing of mammalian tissue, used in techniques such as magnetoencephalography of the brain, require cryogenically cooled superconducting detectors. These have many disadvantages in terms of high cost, flexibility and limited portability as well as poor spatial and temporal resolution. In this work we demonstrate an alternative technique for detecting magnetic fields generated by the current from action potentials in living tissue using nitrogen vacancy centres in diamond. With 50pT/$\sqrt{Hz}$ sensitivity, we show the first measurements of sensing from mammalian tissue with a diamond sensor using mouse muscle optogenetically activated with blue light. We show these measurements can be performed in an ordinary, unshielded lab environment and that the signal can be easily recovered by digital signal processing techniques.
