论文标题
单发杂交光声荧光微型镜通过多模式纤维带有波饰形状
Single-shot hybrid photoacoustic-fluorescent microendoscopy through a multi-mode fiber with wavefront shaping
论文作者
论文摘要
我们基于将光声和荧光传感结合的多模纤维基于多模纤维的最低侵入性内窥镜。从在先前的校准步骤中测量传输矩阵，通过使用快速的空间光调节器，在光纤远端的样品上产生了聚焦点并在样品上进行栅格扫描。将纤维旁边的用于光声检测的超敏感超声传感器与光电探测器结合使用，以获得荧光和光声图像，其远端成像尖端不大于250UM。由基于波前塑形的聚焦和超敏感超声传感器提供的高信噪比，每个像素的单个激光镜头可以进行成像，展示了红细胞和荧光珠的快速二维混合成像。
We present a minimally-invasive endoscope based on a multimode fiber that combines photoacoustic and fluorescence sensing. From the measurement of a transmission matrix during a prior calibration step, a focused spot is produced and raster-scanned over a sample at the distal tip of the fiber by use of a fast spatial light modulator. An ultra-sensitive fiber-optic ultrasound sensor for photoacoustic detection placed next to the fiber is combined with a photodetector to obtain both fluorescence and photoacoustic images with a distal imaging tip no larger than 250um. The high signal-to-noise ratio provided by wavefront shaping based focusing and the ultra-sensitive ultrasound sensor enables imaging with a single laser shot per pixel, demonstrating fast two-dimensional hybrid imaging of red blood cells and fluorescent beads.
