论文标题
天然液泡质子ATPase在振荡电场中的活性 - 神秘化音乐对生物分子的明显影响
The activity of native vacuolar proton-ATPase in an oscillating electric field -- demystifying an apparent effect of music on a biomolecule
论文作者
论文摘要
据报道，音乐对酵母液泡质子ATPase（V-ATPase）活性在其天然环境中产生的振荡电场的影响。电极由浸入酵母液泡膜囊泡的分散体中产生振荡电场，该膜囊泡本来可以托有高浓度的活性V-ATPase。 V-ATPase在最刺激和抑制音乐下的ATP水解活性的实质差异是前所未有的。由于该主题（即音乐对生物分子的影响）对非科学，深奥的神秘化非常有吸引力，因此我们为观察到的新现象提供了合理的解释。在酶的特定活性变化与音乐夹傅立叶光谱的某些频带的组合强度之间发现了良好的相关性。最突出的识别频率在彼此之间和谐相关以及酶的估计旋转速率之间相互关联。这些结果得出的结论是，振荡电场会干扰工作酶中周期性的跨膜电荷运动。
The effect of an oscillating electric field generated from music on yeast vacuolar proton-ATPase (V-ATPase) activity in its native environment is reported. An oscillating electric field is generated by electrodes that are immersed into a dispersion of yeast vacuolar membrane vesicles natively hosting a high concentration of active V-ATPase. The substantial difference in the ATP hydrolysing activity of V-ATPase under the most stimulating and inhibiting music is unprecedented. Since the topic, i.e. an effect of music on biomolecules, is very attractive for non-scientific, esoteric mystification, we provide a rational explanation for the observed new phenomenon. Good correlation is found between changes in the specific activity of the enzyme and the combined intensity of certain frequency bands of the Fourier spectra of the music clips. Most prominent identified frequencies are harmonically related to each other and to the estimated rotation rate of the enzyme. These results lead to the conclusion that the oscillating electric field interferes with periodic trans-membrane charge motions in the working enzyme.
