论文标题
多发性硬化症：一种用于研究其药物相互作用的计算方法
Multiple Sclerosis disease: a computational approach for investigating its drug interactions
论文作者
论文摘要
多发性硬化症（MS）是一种慢性且潜在的高度残疾疾病，可能导致中枢神经系统的永久损害和恶化。在欧洲，这是年轻人非创伤性残疾的主要原因，因为超过70万欧盟患有MS。尽管已经提供了有关MS病理生理学的最新研究，但MS仍然是一种具有挑战性的疾病。在这种情况下，由于软件和硬件技术方面的最新进展，计算模型和计算机模拟变得有吸引力的研究工具，以支持科学家的研究。因此，在本文中，我们提出了一个新的模型，以研究MS在计算机中的演变以及daclizumab药物给药的影响，同时还考虑了所涉及现象的空间性和时间性。此外，我们展示了如何利用系统的内在对称性，以大大降低其分析的复杂性。
Multiple Sclerosis (MS) is a chronic and potentially highly disabling disease that can cause permanent damage and deterioration of the central nervous system. In Europe it is the leading cause of non-traumatic disabilities in young adults, since more than 700,000 EU people suffer from MS. Although recent studies on MS pathophysiology have been provided, MS remains a challenging disease. In this context, thanks to recent advances in software and hardware technologies, computational models and computer simulations are becoming appealing research tools to support scientists in the study of such disease. Thus, motivated by this consideration we propose in this paper a new model to study the evolution of MS in silico, and the effects of the administration of Daclizumab drug, taking into account also spatiality and temporality of the involved phenomena. Moreover, we show how the intrinsic symmetries of the system can be exploited to drastically reduce the complexity of its analysis.
