论文标题
冠状病毒SARS-COV-2基因组中的二核苷酸重复：进化意义
Dinucleotide repeats in coronavirus SARS-CoV-2 genome: evolutionary implications
论文作者
论文摘要
自2019年新小说冠状病毒（SARS-COV-2，以前是2019-NCOV）引起的感染疾病的持续全球大流行对公共卫生和经济构成了关键威胁，自2019年12月在中国确定。SARS-COV-2的基因组已被序列和结构化的众所周知，但众所周知，众所周知，众所周知，众所周知，基因和基因构成了本质上的基因组合。为此，我们提出了一种用于SARS-COV-2和常见人冠状病毒的基因组光谱（一种条形码）的数学方法。基因组光谱是根据核苷酸的周期性分布构建的，因此反映了基因组的独特特征。结果表明，冠状病毒SARS-COV-2在非结构蛋白3、4、5和6中表现出二核苷酸TT岛。对二核苷酸区域的进一步分析表明，在进化过程中增加了二核苷酸重复序列，并且可能赋予病毒进化适应性。在这项研究中鉴定出的SARS-COV-2基因组中的特殊二核苷酸区域可能会成为监测和治愈COVID-19疾病的诊断和药物靶标。
The ongoing global pandemic of infection disease COVID-19 caused by the 2019 novel coronavirus (SARS-COV-2, formerly 2019-nCoV) presents critical threats to public health and the economy since it was identified in China, December 2019. The genome of SARS-CoV-2 had been sequenced and structurally annotated, yet little is known of the intrinsic organization and evolution of the genome. To this end, we present a mathematical method for the genomic spectrum, a kind of barcode, of SARS-CoV-2 and common human coronaviruses. The genomic spectrum is constructed according to the periodic distributions of nucleotides, and therefore reflects the unique characteristics of the genome. The results demonstrate that coronavirus SARS-CoV-2 exhibits dinucleotide TT islands in the non-structural proteins 3, 4, 5, and 6. Further analysis of the dinucleotide regions suggests that the dinucleotide repeats are increased during evolution and may confer the evolutionary fitness of the virus. The special dinucleotide regions in the SARS-CoV-2 genome identified in this study may become diagnostic and pharmaceutical targets in monitoring and curing the COVID-19 disease.
