论文标题
纳米敏感的光学相干断层扫描以评估角膜内的伤口愈合
Nanosensitive optical coherence tomography to assess wound healing within the cornea
论文作者
论文摘要
光学相干断层扫描（OCT）是一种非侵入性深度解析的光学成像方式，可以在临床相关的深度下进行高分辨率，生物组织中的横截面成像和材料。尽管OCT提供了高分辨率成像，但最佳的超高分辨率OCT系统仅限于成像结构变化，而在非常有限的深度内，单个B扫描上的一个微米分辨率。纳米敏感OCT（NSOCT）是一种最近开发的技术，能够提供OCT对结构变化的敏感性增强。将OCT在纳米级检测结构变化的敏感性提高到常规OCT的典型深度，可能会提高OCT在医疗应用中的诊断能力。在本文中，我们证明了NSOCT在浅表角膜损伤后检测大鼠角膜深处的结构变化的能力。
Optical Coherence Tomography (OCT) is a non-invasive depth resolved optical imaging modality, that enables high resolution, cross-sectional imaging in biological tissues and materials at clinically relevant depths. Though OCT offers high resolution imaging, the best ultra-high-resolution OCT systems are limited to imaging structural changes with a resolution of one micron on a single B-scan within very limited depth. Nanosensitive OCT (nsOCT) is a recently developed technique that is capable of providing enhanced sensitivity of OCT to structural changes. Improving the sensitivity of OCT to detect structural changes at the nanoscale level, to a depth typical for conventional OCT, could potentially improve the diagnostic capability of OCT in medical applications. In this paper, we demonstrate the capability of nsOCT to detect structural changes deep in the rat cornea following superficial corneal injury.
