论文标题
双曲线材料纳米颗粒，用于II和III近红外窗户中有效的高温
Hyperbolic Metamaterial Nanoparticles for Efficient Hyperthermia in the II and III Near-Infrared Windows
论文作者
论文摘要
在近红外（NIR）光谱区域中使用金纳米颗粒在高温治疗中，由于潜在的临床治疗应用中的潜在影响，已经催化了实质性的研究工作。然而，使用纳米颗粒体积的平方缩放的照相效果会导致低吸收效率，这阻碍了NIR II区域1000 nm的NIR II区域中金纳米颗粒的实用性。在这里，我们通过引入由多层金/电介质纳米风险制成的双曲线超材料纳米颗粒来征服这一限制，在NIR II和III地区的吸收效率> 70％。与具有相同量的金纳米虫的温度升高相比，它们的温度升高要大得多。具有可忽略的细胞毒性的活细胞的有效体外热疗表明了我们方法对下一代生物医学应用的潜力。
The use of gold nanoparticles for hyperthermia therapy in near infrared (NIR) spectral regions has catalysed substantial research efforts due to the potential impact in clinical therapy applications. However, the photoscattering effect scaling with the square of the nanoparticle volume leads to a low absorption efficiency, which has hindered the utility of gold nanoparticles in NIR II regions above 1000 nm. Here, we conquer this limit by introducing hyperbolic metamaterial nanoparticles that are made of multi-layered gold/dielectric nanodisks and exhibit >70% absorption efficiency in the NIR II and III regions. Their high light-to-heat conversion is demonstrated by a much larger temperature increase than that of gold nanodisks with the same amount of gold. Efficient in vitro hyperthermia of living cells with negligible cytotoxicity shows the potential of our approach for next-generation bio-medical applications.
