论文标题
器官尺寸随肥胖而增加，与癌症风险相关
Organ size increases with obesity and correlates with cancer risk
论文作者
论文摘要
肥胖会增加各种器官的癌症风险。尽管数十年来已经认可了这一点，但这种发生的机制从未被解释过。在这里，我们表明肾脏，胰腺和肝脏的体积密切相关（中位相关= 0.625； p值<10-47）与一个人的体重指数（BMI）。我们还发现器官量的增加与癌症风险增加之间存在显着关系（P值<10-12）。这些结果提供了一种机制，解释了为什么肥胖个体在几个器官中具有较高的癌症风险：器官量越大，癌细胞的风险就越大。这些发现对于更好地理解肥胖对癌症风险的影响很重要，更普遍地，开发了更好的预防策略来限制肥胖引起的死亡率。
Obesity increases significantly cancer risk in various organs. Although this has been recognized for decades, the mechanism through which this happens has never been explained. Here, we show that the volumes of kidneys, pancreas, and liver are strongly correlated (median correlation = 0.625; P-value<10-47) with the body mass index (BMI) of an individual. We also find a significant relationship between the increase in organ volume and the increase in cancer risk (P-value<10-12). These results provide a mechanism explaining why obese individuals have higher cancer risk in several organs: the larger the organ volume the more cells at risk of becoming cancerous. These findings are important for a better understanding of the effects obesity has on cancer risk and, more generally, for the development of better preventive strategies to limit the mortality caused by obesity.
