论文标题

使用移动健康数据估算野生火烟的空间变化的健康效应

Estimating spatially varying health effects of wildland fire smoke using mobile health data

论文作者

Wu, Lili, Gao, Chenyin, Yang, Shu, Reich, Brian J., Rappold, Ana G.

论文摘要

Wildland Fire烟雾暴露是对公共卫生的日益威胁,因此,越来越需要研究保护行为对减少健康结果的影响。新兴的智能手机应用程序提供了前所未有的机会,可以在经历暴露并随后研究有效性的情况下向大量个人传达健康风险交流信息,但也带来了新的方法论挑战。公民科学项目Smoke Sense为参与者提供了一个互动的智能手机应用程序平台,可以参与有关空气质量以及保护其健康并记录其自身健康症状和减少烟雾暴露所采取的行动的信息。我们提出了一个新的,双重稳健的估计器的结构嵌套平均模型参数,该参数通过局部估计方程方法和地理内核加权来解释空间和时间变化的效果。此外,我们的分析框架足够灵活,可以通过估计功能的反概率加权来处理信息性缺失。我们使用广泛的仿真研究评估了新方法,并将其应用于公民科学家报告的烟雾感数据,以增加有关健康预防措施和改善健康结果之间关系的知识基础。我们的结果估计,保护行为在时间和时间上的影响如何变化,发现保护行为对减少西南地区的健康症状的影响比美国西北地区更为重要。

Wildland fire smoke exposures are an increasing threat to public health, and thus there is a growing need for studying the effects of protective behaviors on reducing health outcomes. Emerging smartphone applications provide unprecedented opportunities to deliver health risk communication messages to a large number of individuals when and where they experience the exposure and subsequently study the effectiveness, but also pose novel methodological challenges. Smoke Sense, a citizen science project, provides an interactive smartphone app platform for participants to engage with information about air quality and ways to protect their health and record their own health symptoms and actions taken to reduce smoke exposure. We propose a new, doubly robust estimator of the structural nested mean model parameter that accounts for spatially- and time-varying effects via a local estimating equation approach with geographical kernel weighting. Moreover, our analytical framework is flexible enough to handle informative missingness by inverse probability weighting of estimating functions. We evaluate the new method using extensive simulation studies and apply it to Smoke Sense data reported by the citizen scientists to increase the knowledge base about the relationship between health preventive measures and improved health outcomes. Our results estimate how the protective behaviors effects vary over space and time and find that protective behaviors have more significant effects on reducing health symptoms in the Southwest than the Northwest region of the USA.

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