论文标题

从社区获得的肺炎诊断的双重采样注意网络,用于诊断COVID-19

Dual-Sampling Attention Network for Diagnosis of COVID-19 from Community Acquired Pneumonia

论文作者

Ouyang, Xi, Huo, Jiayu, Xia, Liming, Shan, Fei, Liu, Jun, Mo, Zhanhao, Yan, Fuhua, Ding, Zhongxiang, Yang, Qi, Song, Bin, Shi, Feng, Yuan, Huan, Wei, Ying, Cao, Xiaohuan, Gao, Yaozong, Wu, Dijia, Wang, Qian, Shen, Dinggang

论文摘要

冠状病毒疾病(Covid-19)迅速在世界各地迅速传播,截至2020年4月9日,在200多个国家和领土上感染了1,436,000多人。在早期发现Covid-19,对于为患者提供适当的医疗保健至关重要,也至关重要。为此,我们开发了一个双重采样的注意网络,以自动从社区获得的COVID-19在胸部计算机断层扫描(CT)中自动诊断出肺炎(CAP)。特别是,我们提出了一个具有3D卷积网络(CNN)的新型在线注意模块,以专注于诊断决定时的肺部感染区域。请注意,由于症状发作后COVID-19的快速进展,在Covid-19和CAP之间,感染区域的大小分布不平衡。因此,我们制定了双重采样策略来减轻不平衡的学习。 (就我们最大的知识而言,我们的方法对8家医院的COVID-19的最大多中心CT数据进行了评估。在训练验证阶段,我们从1588例患者中收集2186张CT扫描,用于5倍的交叉验证。在测试阶段,我们采用了另一项独立的大规模测试数据集,包括2057名患者的2796张CT扫描。结果表明,我们的算法可以鉴定与接收器操作特征曲线(AUC)值0.944的区域下的COVID-19图像,精度为87.5%,灵敏度为86.9%,特异性为90.1%,F1评分评分为82.0%。通过这种性能,提出的算法可以潜在地帮助放射线医生,从CAP中进行COVID-19诊断,尤其是在Covid-19-19-19爆发的早期阶段。

The coronavirus disease (COVID-19) is rapidly spreading all over the world, and has infected more than 1,436,000 people in more than 200 countries and territories as of April 9, 2020. Detecting COVID-19 at early stage is essential to deliver proper healthcare to the patients and also to protect the uninfected population. To this end, we develop a dual-sampling attention network to automatically diagnose COVID- 19 from the community acquired pneumonia (CAP) in chest computed tomography (CT). In particular, we propose a novel online attention module with a 3D convolutional network (CNN) to focus on the infection regions in lungs when making decisions of diagnoses. Note that there exists imbalanced distribution of the sizes of the infection regions between COVID-19 and CAP, partially due to fast progress of COVID-19 after symptom onset. Therefore, we develop a dual-sampling strategy to mitigate the imbalanced learning. Our method is evaluated (to our best knowledge) upon the largest multi-center CT data for COVID-19 from 8 hospitals. In the training-validation stage, we collect 2186 CT scans from 1588 patients for a 5-fold cross-validation. In the testing stage, we employ another independent large-scale testing dataset including 2796 CT scans from 2057 patients. Results show that our algorithm can identify the COVID-19 images with the area under the receiver operating characteristic curve (AUC) value of 0.944, accuracy of 87.5%, sensitivity of 86.9%, specificity of 90.1%, and F1-score of 82.0%. With this performance, the proposed algorithm could potentially aid radiologists with COVID-19 diagnosis from CAP, especially in the early stage of the COVID-19 outbreak.

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