论文标题
皮质神经肽和突触网络可塑性的新光
New Light on Cortical Neuropeptides and Synaptic Network Plasticity
论文作者
论文摘要
神经肽是蛋白质细胞 - 细胞信号分子的大型且进化古老的家族的成员，被广泛认为是脑功能和行为的极有效调节剂。在细胞水平上，已知神经肽主要通过离子通道和突触功能的调节作用，但是在复杂的皮质突触网络水平上出现的功能影响已经抵抗了机械分析。现在，来自单细胞RNA-seq转录组学的新发现阐明了皮质神经肽信号传导基因表达和新工具的复杂模式，现在为皮质神经肽信号传导提供了强大的分子访问。在这里，我们重点介绍了其中一些新的发现和工具，尤其着重于对肽基和突触网络相互作用的皮质功能和可塑性的实验和理论探索的前景。
Neuropeptides, members of a large and evolutionarily ancient family of proteinaceous cell-cell signaling molecules, are widely recognized as extremely potent regulators of brain function and behavior. At the cellular level, neuropeptides are known to act mainly via modulation of ion channel and synapse function, but functional impacts emerging at the level of complex cortical synaptic networks have resisted mechanistic analysis. New findings from single-cell RNA-seq transcriptomics now illuminate intricate patterns of cortical neuropeptide signaling gene expression and new tools now offer powerful molecular access to cortical neuropeptide signaling. Here we highlight some of these new findings and tools, focusing especially on prospects for experimental and theoretical exploration of peptidergic and synaptic networks interactions underlying cortical function and plasticity.
