论文标题
分子电动机的双向运输中的自组织车道形成
Self-organized lane-formation in bidirectional transport of molecular motors
论文作者
论文摘要
在细胞内，囊泡和蛋白质沿细胞骨骼细丝的几微米积极运输。沿微管的运输是由动力蛋白和驱动蛋白电动机推动的，这些电动机将货物沿相反的方向携带。双向细胞内转运的效率也很高，即使在强限制下，例如在轴突中。对于这种运输系统，人们会期望一般的集群形成。在这项工作中，我们讨论了最近观察到的沿MT上的驱动蛋白轨迹的自我增强结合亲密关系的效果。我们引入了随机的晶状体气体模型，其中增强的结合亲和力是通过地板场实现的。从蒙特卡洛模拟和平均场分析中，我们表明这种机制可以导致自组织的对称性和车道形成，这确实导致了狭窄环境中有效的双向传输。
Within cells, vesicles and proteins are actively transported several micrometers along the cytoskeletal filaments. The transport along microtubules is propelled by dynein and kinesin motors, which carry the cargo in opposite directions. Bidirectional intracellular transport is performed with great efficiency, even under strong confinement, as for example in the axon. For this kind of transport system, one would expect generically cluster formation. In this work, we discuss the effect of the recently observed self-enhanced binding-affinity along the kinesin trajectories on the MT. We introduce a stochastic lattice-gas model, where the enhanced binding affinity is realized via a floor-field. From Monte Carlo simulations and a mean-field analysis we show that this mechanism can lead to self-organized symmetry-breaking and lane-formation which indeed leads to efficient bidirectional transport in narrow environments.
