论文标题
慢性胎儿缺氧和炎症对心脏起搏器细胞发育的影响
Impact of chronic fetal hypoxia and inflammation on cardiac pacemaker cell development
论文作者
论文摘要
慢性胎儿缺氧和感染是复杂怀孕期间不良状况的例子，这会影响心脏肌发生并增加心脏病的终生风险。然而，对心脏起搏器细胞的慢性低氧或炎症环境的影响知之甚少。在这里，我们回顾了围产期心脏病学领域基准研究的当前证据和新颖的途径，以及其对早期发现心血管疾病未来风险的转化意义。
Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease. However, the effects that chronic hypoxic or inflammatory environments exert on cardiac pacemaker cells are poorly understood. Here, we review the current evidence and novel avenues of bench-to-bed research in this field of perinatal cardiogenesis as well as its translational significance for early detection of future risk for cardiovascular disease.
