论文标题
从蛋白质中的天然接触预测 - 均衡的协调过程
Prediction of native contacts in proteins from an out--of--equilibrium coevolutionary process
论文作者
论文摘要
同源蛋白质中残基的共同进化是预测其天然构象的强大工具。 The standard framework in which coevolutionary analysis is usually worked out is that of equilibrium Potts models, assuming that proteins have evolved for enough time to reach thermodynamic equilibrium in sequence space.在这里，我们提出了一个模型，以根据蛋白质进化动力学的明确描述来描述序列中的相关性。我们表明，此过程改善了对基于平衡模型的天然接触的正确预测。
The analysis of coevolution of residues in homologous proteins is a powerful tool to predict their native conformation. The standard framework in which coevolutionary analysis is usually worked out is that of equilibrium Potts models, assuming that proteins have evolved for enough time to reach thermodynamic equilibrium in sequence space. Here we propose a model to describe correlations in sequences based on an explicit description of the evolutionary kinetics of proteins. We show that this procedure improves the correct prediction of native contacts with respect to equilibrium--based models.
