论文标题
信号网络的学习：分子机制
Learning of signaling networks: molecular mechanisms
论文作者
论文摘要
神经元学习的分子过程已经很好地描述了。但是，非神经元细胞的学习机制尚未在分子水平上完全理解。在这里，我们讨论了细胞学习的分子机制，包括固有无序蛋白质和prions的构象记忆，信号级联，蛋白质易位，RNA，RNA（microRNA和LNCRNA）和染色质记忆。我们假设这些过程构成了信号网络的学习，并且对应于单个非神经细胞的普遍学习过程，并讨论细胞学习如何在药物设计中打开新的方向并激发新的人工智能方法。
Molecular processes of neuronal learning have been well-described. However, learning mechanisms of non-neuronal cells have not been fully understood at the molecular level. Here, we discuss molecular mechanisms of cellular learning, including conformational memory of intrinsically disordered proteins and prions, signaling cascades, protein translocation, RNAs (microRNA and lncRNA), and chromatin memory. We hypothesize that these processes constitute the learning of signaling networks and correspond to a generalized Hebbian learning process of single, non-neuronal cells, and discuss how cellular learning may open novel directions in drug design and inspire new artificial intelligence methods.
