论文标题
关于冷大气等离子体的抗癌作用以及过氧化氢酶依赖性凋亡途径的可能作用
On the anti-cancer effect of cold atmospheric plasma and the possible role of catalase-dependent apoptotic pathways
论文作者
论文摘要
冷大气血浆（CAP）是（选择性）癌症治疗的有前途的新药物，但是尚未很好地了解CAP抗癌作用的根本原因。在不同的理论和观察中，特别详细地假定了一种理论，由一个非常复杂的反应网络组成，这些反应网络被认为是CAP的抗癌作用。在这里，关键概念是通过CAP引起的过氧化氢酶灭活的两个特定凋亡细胞信号通路的重新激活。因此，据推测，CAP的抗癌作用是由于其直接或间接使过氧化氢酶失活的能力。对拟议理论的理论研究，尤其是过氧化氢酶灭活的作用，可以有助于理解CAP抗癌作用的根本原因。在本研究中，我们开发了一个数学模型，以分析CAP的依赖性过氧化氢酶依赖性抗癌作用。我们的结果表明，两种感兴趣的凋亡途径的过氧化氢酶依赖性重新激活不可能有助于观察到的CAP的抗癌作用。因此，我们认为应考虑并评估根本原因的其他理论，以了解帽诱导的癌细胞死亡原理。
Cold atmospheric plasma (CAP) is a promising new agent for (selective) cancer treatment, but the underlying cause of the anti-cancer effect of CAP is not well understood yet. Among different theories and observations, one theory in particular has been postulated in great detail and consists of a very complex network of reactions that are claimed to account for the anti-cancer effect of CAP. Here, the key concept is a reactivation of two specific apoptotic cell signaling pathways through catalase inactivation caused by CAP. Thus, it is postulated that the anti-cancer effect of CAP is due to its ability to inactivate catalase, either directly or indirectly. A theoretical investigation of the proposed theory, especially the role of catalase inactivation, can contribute to the understanding of the underlying cause of the anti-cancer effect of CAP. In the present study, we develop a mathematical model to analyze the proposed catalase-dependent anti-cancer effect of CAP. Our results show that a catalase-dependent reactivation of the two apoptotic pathways of interest is unlikely to contribute to the observed anti-cancer effect of CAP. Thus, we believe that other theories of the underlying cause should be considered and evaluated to gain knowledge about the principles of CAP-induced cancer cell death.
