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For a graph $G$, a vertex subset $S \subseteq V(G)$ is said to be $K_{k}$-isolating if $G - N_{G}[S]$ does not contain $K_{k}$ as a subgraph. The $K_{k}$-isolation number of $G$, denoted by $ι_{k}(G)$, is the minimum cardinality of a $K_{k}$-isolating set of $G$. Analogously, $S$ is said to be independent $K_{k}$-isolating if $S$ is a $K_{k}$-isolating set of $G$ and $G[S]$ has no edge. The independent $K_{k}$-isolation number of $G$, denoted by $ι'_{k}(G)$, is the minimum cardinality of an independent $K_{k}$-isolating set of $G$. Clearly, when $k = 1$, we have $γ(G) = ι_{1}(G)$ and $i(G) = ι'_{1}(G)$ where $γ(G)$ and $i(G)$ are the domination and independent domination numbers. For classic results between $γ(G)$ and $i(G)$, in 1978, Allan and Laskar proved that $γ(G) = i(G)$ for all $K_{1, 3}$-free graphs and this result was generalized to $K_{1, r}$-free graphs by Bollob$\acute{a}$s and Cockayne in 1979. In 2013, Rad and Volkmann proved that the ratio $i(G)/γ(G)$ is at most $Δ(G)/2$ when $Δ(G) \in \{3, 4, 5\}$. Further, Furuya et. al. proved that when $Δ(G) \geq 6$, we have $i(G)/γ(G) \leq Δ(G) - 2\sqrt{Δ(G)} + 2$. In this paper, for a smallest $K_{k}$-isolating set $S$, we prove that $ι'_k(G)\le -\frac{ι_k^2(G)}{\ell} +i_k(G)(Δ+2)-\ell Δ$ where $\ell$ is the number of some specific vertices of $S$ such that the union of their closed neighborhoods in $S$ is $S$. We prove that this bound is sharp. A special case of our main theorem implies $ι'_{k}(G)/ι_{k}(G) \leq Δ(G) - 2\sqrt{Δ(G)} + 2$. Further, we find an inequality between $ι'_{k}(G)$ and $ι_{k}(G)$ when $G$ is $K_{1, r}$-free graph. This also generalizes the result of Bollob$\acute{a}$s and Cockayne.