论文标题
朝着新的爆发模式分类:审查和扩展
Towards a new classification of bursting patterns: review & extensions
论文作者
论文摘要
自1980年代初以来,在物理和神经科学中看到的多尺度激发系统中复杂爆发振荡的数学分类一直是主动查询的主题。此分类问题是基本的,因为它还建立了用于研究多个时间尺度模型中复杂的时间行为的分析和数值基础。该手稿首先回顾了Rinzel和Izhikevich的开创性作品,以分类可激发细胞模型的爆发模式。此外,我们回想起Golubitsky的一种替代但互补的数学分类方法,该方法与Rinzel-Ishikevich的建议一起为分类问题提供了最新的基础。出乎意料的是,在保持Rinzel-izhikevich框架内时,我们发现了以前未考虑的新型爆发机制的新案例。超越了最新的,我们确定了新的爆发机制,这些机制不在当前的分类之外。这使我们朝着一个新的分类迈进,这需要对基础慢速模型的快速和慢速子系统进行分析。这种新的分类允许对较大类的毛毛进行动态解剖。为了证实这一点,我们添加了一个至少两个慢变量的新类囊泡,我们表示折叠的节点毛毛,以传达出爆发是通过折叠节点奇异性启动或歼灭的想法。实际上,有两个主要的折叠节点毛毛的家族,具体取决于发生折叠节点动力学的爆发循环的阶段。如果在静音阶段发生,我们将获得经典的折叠节点爆发(或简单地折叠节点爆发)。如果在活动阶段发生,我们会有循环折叠节点爆发。我们对两个家庭进行了分类,并给出了显示这些新型爆发行为类型的最小系统的示例。
The mathematical classification of complex bursting oscillations in multiscale excitable systems, seen for example in physics and neuroscience, has been the subject of active enquiry since the early 1980s. This classification problem is fundamental as it also establishes analytical and numerical foundations for studying complex temporal behaviours in multiple timescale models. This manuscript begins by reviewing the seminal works of Rinzel and Izhikevich in classifying bursting patterns of excitable cell models. Moreover, we recall an alternative, yet complementary, mathematical classification approach by Golubitsky, which together with the Rinzel-Izhikevich proposals provide the state-of-the-art foundations to the classification problem. Unexpectedly, while keeping within the Rinzel-Izhikevich framework, we find novel cases of bursting mechanisms not considered before. Moving beyond the state-of-the-art, we identify novel bursting mechanisms that fall outside the current classifications. This leads us towards a new classification, which requires the analysis of both the fast and the slow subsystems of an underlying slow-fast model. This new classification allows the dynamical dissection of a larger class of bursters. To substantiate this, we add a new class of bursters with at least two slow variables, which we denote folded-node bursters, to convey the idea that the bursts are initiated or annihilated via a folded-node singularity. In fact, there are two main families of folded-node bursters, depending upon the phase of the bursting cycle during which folded-node dynamics occurs. If it occurs during the silent phase, we obtain the classical folded-node bursting (or simply folded-node bursting). If it occurs during the active phase, we have cyclic folded-node bursting. We classify both families and give examples of minimal systems displaying these novel types of bursting behaviour.