论文标题
噪声控制和实用程序：从监管网络到空间图案
Noise control and utility: from regulatory network to spatial patterning
论文作者
论文摘要
在细胞和分子水平上的随机性（或噪声）已被广泛地视为生活系统的通用特征。但是，在执行理想的生物学功能时，生活系统如何处理噪音仍然是一个主要的谜。调节网络配置（例如其拓扑结构和时间尺度）在减弱噪声方面至关重要，并且还发现噪声促进了细胞命运的决策。在这里，我们回顾了通过调节控制，关于噪声衰减的主要发现，通过噪声引起的发育模式期间噪声诱导的噪声益处，并概述了噪声控制的基础关键原理。
Stochasticity (or noise) at cellular and molecular levels has been observed extensively as a universal feature for living systems. However, how living systems deal with noise while performing desirable biological functions remains a major mystery. Regulatory network configurations, such as their topology and timescale, are shown to be critical in attenuating noise, and noise is also found to facilitate cell fate decision. Here we review major recent findings on noise attenuation through regulatory control, the benefit of noise via noise-induced cellular plasticity during developmental patterning, and summarize key principles underlying noise control.
