论文标题
细胞骨架极性对于确定多细胞基体的定向顺序至关重要
Cytoskeleton polarity is essential in determining orientational order in basal bodies of multi-ciliated cells
论文作者
论文摘要
在气管中同步和定向睫状跳动可以从体内运输和弹出病毒和灰尘。这种睫状功能取决于顶部细胞膜中基体（纤毛根）的协调构型。但是，其形成的机制仍然未知。在这项研究中，我们表明，顶部微管束的极性在基础体的组织中起着重要作用。已经制定了一种结合极性的数学模型，该模型提供了一个连贯的解释，并能够再现实验观测。我们已经阐明了细胞骨架极性的充分性（“如何形成模式形成”）和充分性（“如何为模式形成起作用”），以通过实验数据验证基底体的正确模式。该模型进一步导致我们建立了一种可能的细胞手性机制。
Synchronous and directed ciliary beating in trachea allows transport and ejection of virus and dust from the body. This ciliary function depends on the coordinated configuration of basal bodies (root of cilia) in apical cell membrane. However, the mechanism for their formation remains unknown. In this study, we show that the polarity in apical microtubule bundles plays a significant role in the organization of basal bodies. A mathematical model incorporating polarity has been formulated which provides a coherent explanation and is able to reproduce experimental observations. We have clarified both necessity ('why polarity is required for pattern formation') and sufficiency ('how polarity works for pattern formation') of cytoskeleton polarity for correct pattering of basal bodies with verification by experimental data. This model further leads us to a possible mechanism for cellular chirality.
